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Your Position: Home > Protein > E-Selectin > CDE-M52H3

Mouse E-Selectin Protein, His Tag (MALS verified)

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  • Synonym
    SELE,RP1-117P20.2,CD62E,ELAM1,ESEL,LECAM2,E-Selectin
  • Source
    Mouse E-Selectin Protein, His Tag(CDE-M52H3) is expressed from human 293 cells (HEK293). It contains AA Trp 22 - Arg 556 (Accession # Q00690).
    Predicted N-terminus: Trp 22
  • Molecular Characterization
    E-Selectin Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 60.3 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
E-Selectin SDS-PAGE

Mouse E-Selectin Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
E-Selectin MALS images

The purity of Mouse E-Selectin Protein, His Tag (Cat. No. CDE-M52H3) is more than 90% and the molecular weight of this protein is around 65-95 kDa verified by SEC-MALS.

  • Background
    E-Selectin, a key member of the selectin family, is an adhesion molecule primarily expressed on vascular endothelial cells upon stimulation by pro-inflammatory cytokines like IL-1 and TNF-α. E-Selectin mediates the initial rolling of leukocytes on endothelium via recognizing sialyl Lewis X ligands, a critical step for leukocyte recruitment to inflamed tissues. It also participates in amplifying inflammatory responses and is implicated in pathological processes such as atherosclerosis and tumor metastasis. Its induced expression and ligand specificity make it a pivotal player in immune surveillance and inflammation.
  • Clinical and Translational Updates

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  • Number of Drugs in Clinical Trials:4 Details
  • Latest Research Phase:Phase 3 Clinical

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