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Your Position: Home > Reporter Cell Lines
Reporter Cell Lines
Background
Application Scenarios
Product list
References
Background
Antibody drugs have undergone decades of research and development after the world’s first monoclonal antibody drug, muromonab-CD3. Antibody therapies have become the fastest growing biological drug field and have revolutionized the treatment landscape for wide array of diseases, especially in cancer. Presently, over 100 antibody drugs have been commercialized across the globe, playing an important role in clinical treatment in vitro diagnostics, research, and many other fields.
Cellular-level evaluation is a key indicator for drug efficacy in vitro and is widely used throughout the drug development process. However, when using conventional cells, many traditional analytical methods have disadvantages including low sensitivity, poor reproducibility, complicated operations, and low throughput. This is further exacerbated by the batch-to-batch variation in primary cells, and results in a significant bottleneck during antibody drug development.
Instead of using traditional cells, our reporter cell lines are constructed using genetic engineering to help standardize and minimize the batch-to-batch variation during cell passaging. Reporter cell lines are based on the drug mechanism of action (MOA) and helps various studies, including:
Establish the correlation between the target transduction signal and the reporter gene expression in the cell.
Monitor the target signaling pathway by detecting the expression of the reporter gene transduction.
To meet the needs of new drug development, ACROBiosystems uses a luciferase reporter gene system to establish a reporter gene cell platform and continues to develop a series of high-quality reporter gene cell line products. The series of cell line products are verified for functionality and stability and designed to be applied to signal transduction function research, early drug discovery and screening, and CMC quality control release!

Application Scenarios

ADCC/ADCP Functional Valification

ADCC/ADCP Functional Valification

Target & Transduction Research

Target & Transduction Research

Cross-linking Drug Evaluation

Cross-linking Drug Evaluation

CD3/TAA BsAb Evaluation

CD3/TAA BsAb Evaluation

Immune Checkpoint
Drug Evaluation

Immune Checkpoint Drug Evaluation

Neuroscience

Neuroscience

Diabetes & Obesity & NASH
Drug Evaluation

Diabetes & Obesity & NASH Drug Evaluation

Autoimmunity Drug Evaluation

Autoimmunity Drug Evaluation

Click here to learn more about customizing cell lines!
Product advantage

Designed for the verification of drug mechanism-of-actions.

Strong response signal ensures high sensitivity.

Verified stable passage for more than 20 generations.

Supporting product supply to achieve a one-stop service.

Large detection window that is suitable for screening of different drug effects.

Regulatory document support.

Product List
  • ADCC/ADCP functional verification
  • Target & transduction research
  • Cross-linking drug evaluation
  • CD3/TAA BsAb Evaluation
  • Immune Checkpoint Drug Evaluation
  • Neuroscience
  • Diabetes & Obesity & NASH Drug Evaluation
  • Autoimmunity Drug Evaluation
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description
Molecule Cat. No. Product description

Relevant Cell Line Services

Relevant Cell Line Services
Relevant Cell Line Services
References

[1]. Singh A, Dees S, Grewal IS. Overcoming the challenges associated with CD3+ T-cell redirection in cancer. Br J Cancer. 2021;124(6):1037-1048. doi:10.1038/s41416-020-01225-5

[2]. Raimondo L, Oliveira ĹAF, Heij J, et al. Advances in resting state fMRI acquisitions for functional connectomics. Neuroimage. 2021;243:118503. doi:10.1016/j.neuroimage.2021.118503

[3]. Boland ML, Laker RC, Mather K, et al. Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. Nat Metab. 2020;2(5):413-431. doi:10.1038/s42255-020-0209-6

[4]. Xue C, Yao Q, Gu X, et al. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Ther. 2023;8(1):204. Published 2023 May 19. doi:10.1038/s41392-023-01468-7

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