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Your Position: Home > ACE2

ACE2

Brief Information

Name:Angiotensin-converting enzyme 2
Target Synonym:Angiotensin-converting enzyme homolog,Metalloprotease MPROT15,ACEH,Angiotensin I Converting Enzyme 2,Angiotensin-converting enzyme-related carboxypeptidase,Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2,Peptidyl-Dipeptidase A,ACE-related carboxypeptidase
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
AC2-HP2H3 Human PE-Labeled Human ACE2 / ACEH Protein, His TagStar Staining
AC2-HP2H3-structure
AC2-M52H3 Mink Mink ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-M52H3-structure
AC2-M52H3-sds
AC2-H82E8 Human Biotinylated Monomeric Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E8-structure
AC2-H82E8-sds
AC2-H52H4 Human Human ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-H52H4-sds
AC2-H82E7 Human Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E7-sds
AC2-H5255 Human Human ACE2 / ACEH Protein, Fc Tag (MALS verified)
AC2-H5255-sds
AC2-H5205 Human Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified)
AC2-H5205-structure
AC2-H5205-sds
MBS-K013 - Human ACE2-coupled Magnetic Beads
AC2-P5248 Paguma larvata Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)
AC2-P5248-structure
AC2-P5248-sds
AC2-M5248 Mouse Mouse ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-M5248-structure
AC2-M5248-sds
AC2-R5246 Rat Rat ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-R5246-structure
AC2-R5246-sds
AC2-C52H7 Cynomolgus Cynomolgus ACE2 / ACEH Protein, His Tag
AC2-C52H7-structure
AC2-C52H7-sds
AC2-H5257 Human Human ACE2 / ACEH Protein, Fc Tag (MALS verified)
AC2-H5257-structure
AC2-H5257-sds
AC2-H52H8 Human Human ACE2 / ACEH Protein, His Tag (MALS verified)
AC2-H52H8-structure
AC2-H52H8-sds
AC2-H82E6 Human Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)
AC2-H82E6-structure
AC2-H82E6-sds
AC2-H82F9 Human Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™
AC2-H82F9-structure
AC2-H82F9-sds
ACRO Quality

Part of Bioactivity data

AC2-M52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mink ACE2, His Tag (Cat. No. AC2-M52H3) immobilized on CM5 Chip can bind SARS-CoV-2 S protein RBD (Y453F), His Tag (Cat. No. SPD-C52Hk) with an affinity constant of 0.178 μM as determined in a SPR assay (Biacore T200) (QC tested).

Protocol
AC2-M52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Mink ACE2, His Tag (Cat. No. AC2-M52H3) immobilized on CM5 Chip can bind SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3) with an affinity constant of 8.34 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

ACE-2,ACEH,ACE2

Background

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

Clinical and Translational Updates

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