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Your Position: Home > NRG1 Beta 1

NRG1 Beta 1

Brief Information

Name:Neuregulin-1
Target Synonym:Sensory and motor neuron-derived factor,Pro-neuregulin-1, membrane-bound isoform,Glial growth factor,Neuregulin-1,Acetylcholine receptor-inducing activity,Pro-NRG1,ARIA,Breast cancer cell differentiation factor p45,Neu differentiation factor,Heregulin,HRG
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
NR1-H5246 Human Human NRG1 Beta 1 Protein, His Tag, premium grade
NR1-H5246-structure
NR1-H5246-sds
NR1-H5268 Human Human NRG1 Beta 1 Protein, Fc Tag, premium grade
NR1-H5268-structure
NR1-H5268-sds
ACRO Quality

Part of Bioactivity data

NR1-H5268-ELISA
NRG1 Beta 1 ELISA

Immobilized Human ErbB3, His Tag (Cat. No. ER3-H5223) at 2 μg/mL (100 μL/well) can bind Human NRG1 Beta 1, Fc Tag, premium grade (Cat. No. NR1-H5268) with a linear range of 0.5-8 ng/mL (QC tested).

Protocol

Synonym Name

NRG1 Beta 1,HRG1 beta 1,Neuregulin-1 beta 1,Neuregulin1 beta 1,NRG1,ARIA,GGF,HGL,HRGA,NDF,SMDF

Background

NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

Clinical and Translational Updates

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