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RON

Brief Information

Name:Macrophage-stimulating protein receptor
Target Synonym:EC 2.7.10.1,Protein-Tyrosine Kinase 8,RON,Macrophage-Stimulating Protein Receptor,SEA,S13 Erythroblastosis Oncogene Homolog,S13 Erythroblastosis (Avian) Oncogene Homolog,Macrophage Stimulating 1 Receptor,PTK8 Protein Tyrosine Kinase 8,S13 Avian Erythroblastosis Oncogene Homolog,MST1R,NPCA3,CD136 Antigen,C-Met-Related Tyrosine Kinase,CD136,CDw136,PTK8,P185-Ron,EC:2.7.10.1,MSP Receptor,EC 2.7.10
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
RON-H52H9 Human Human RON / MSPR Protein, His Tag (MALS verified)
RON-H52H9-structure
RON-H52H9-sds
ACRO Quality

Synonym Name

CD136 antigen,CD136,CDw136c-met-related tyrosine kinase,EC 2.7.10,EC 2.7.10.1,macrophage stimulating 1 receptor (c-met-related tyrosine kinase),MSP R,MSP receptor,MSPR,MST1R,p185-Ron,Protein-tyrosine kinase 8,PTK8 protein tyrosine kinase 8,PTK8,Ron,RONmac

Background

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Crizotinib PF-1066; PF-2341066; PF-02341066; PF-002341066 Approved Pfizer Pharmaceuticals Ltd (China) 赛可瑞, Xalkori EU Lymphoma, Large-Cell, Anaplastic Pfizer Europe Ma Eeig 2011-08-26 Neuroblastoma; Neoplasm Metastasis; Neurilemmoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Granuloma, Plasma Cell; Lymphoma; Lung Neoplasms; Lymphoma, Large-Cell, Anaplastic; Ureteral Neoplasms; Hematologic Neoplasms; Urethral Neoplasms; Myofibroma; Prostatic Neoplasms, Castration-Resistant; Uveal melanoma; Multiple Myeloma; Urinary Bladder Neoplasms; Kidney Diseases; Neurofibromatosis 2; Neoplasms; Solid tumours Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Narnatumab Eli Lilly And Company Details
Glesatinib 7Q29OXD98N; MG-90265H9; MG-90265gly; MG-90265; MG-90265X; MGCD-265 Phase 2 Clinical Mirati Therapeutics Inc Neoplasms; Carcinoma, Non-Small-Cell Lung Details
Ningetinib Tosylate CT-053-PTSA; CT-053 Phase 2 Clinical Hec Pharm Co Ltd Solid tumours; Intestinal Neoplasms; Stomach Neoplasms; Carcinoma, Renal Cell; Lung Neoplasms; Leukemia, Myeloid, Acute; Carcinoma, Non-Small-Cell Lung Details

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