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ADORA2A

Brief Information

Name:Adenosine A2a receptor
Target Synonym:Adenosine receptor A2a,ADORA2A,Adenosine A2a Receptor,ADORA2,Adenosine Receptor Subtype A2a,A2aR,RDC8,Receptor, Adenosine A2A
Number of Launched Drugs:45
Number of Drugs in Clinical Trials:22
Lastest Research Phase:Approved

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
A2aR/A2bR Antagonist Small molecule Oncology/Cancer Advanced solid tumor,Advanced hematological tumor IND Global  (except China)

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By Product Category:
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By Conjugate:
Cat. No. Species Product Description Structure Purity Feature
ADA-H52D3 Human Human ADORA2A Protein, Flag,His Tag (Detergent)
ADA-H52D3-sds
ADA-H52P4 Human Human ADORA2A Full Length Protein (VLP)
ADA-H52P4-hplc
ACRO Quality

Part of Bioactivity data

ADA-H52H5-SPR
 ADORA2A SPR

Anti-ADORA2A antibody-3F6-9G5 captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human ADORA2A Protein, His Tag (Cat. No. ADA-H52H5) with an affinity constant of 21.8 nM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

ADA-H52P4-ELISA
 ADORA2A ELISA

Immobilized Human ADORA2A Full Length Protein-VLP (Cat. No. ADA-H52P4) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human ADORA2A antibody, Human IgG1 with a linear range of 0.3-5 ng/mL (QC tested).

Synonym Name

ADORA2A,adenosine A2a receptor,A2aR, ADORA2, RDC8

Background

Adenosine Receptor Subtype A2a (ADORA2A) is a G-protein coupled adenosine receptor encoded by the ADORA2A gene. It is mainly involved in pathophysiological processes including neuroinflammation, synaptic plasticity in glutamatergic synapses and neurogenes

Clinical and Translational Updates

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