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Your Position: Home > EpCAM

EpCAM

Brief Information

Name:Epithelial cell adhesion molecule
Target Synonym:Epithelial Cell Adhesion Molecule,Tumor-Associated Calcium Signal Transducer 1,Major Gastrointestinal Tumor-Associated Protein GA733-2,Cell Surface Glycoprotein Trop-1,Epithelial Glycoprotein 314,TROP1,KSA,Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein),Antigen Identified By Monoclonal Antibody AUA1,Human Epithelial Glycoprotein-2,Epithelial Cell Surface Antigen,CD326 Antigen,HEGP314,HNPCC8,Ep-CAM,DIAR5,EGP-2,EGP40,KS1/4,MK-1,M1S2,ESA,Ly74,TACST-1,CO-17A,17-1A,EGP34,HEA125,M
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

Antibody Licensing

Project Name Project Stage Molecule Type Host Species Therapeutic Area Indications
EpCAM CAR-T -01 IIT Solid Tumor Gastric Cancer

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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP175 Human HEK293/Human EpCAM Stable Cell Line
EPM-R82E3 Rhesus macaque Biotinylated Rhesus macaque EpCAM / TROP1 Protein, His,Avitag™ (MALS verified)
EPM-R82E3-structure
EPM-R82E3-sds
HGS-S265 Rabbit Recombinant Monoclonal Anti-EpCAM Antibody, Rabbit (6C3)
EPM-H5259 Human Human EpCAM / TROP1 Protein, Llama IgG2b Fc Tag, low endotoxin
EPM-H5259-structure
EPM-H5259-sds
EPM-H5255 Human Human EpCAM / TROP1 Protein, Mouse IgG2a Fc Tag
EPM-H5255-structure
EPM-H5255-sds
EPM-HF255 Human FITC-Labeled Human EpCAM / TROP1 Protein, Fc Tag
EPM-HF255-structure
EPM-HF255-sds
EPM-HF225 Human FITC-Labeled Human EpCAM / TROP1 Protein, His Tag
EPM-HF225-structure
EPM-HF225-sds
EPM-H82F9 Human Biotinylated Human EpCAM / TROP1 Protein, Fc,Avitag™ (MALS verified)
EPM-H82F9-structure
EPM-H82F9-sds
EPM-H82E8 Human Biotinylated Human EpCAM / TROP1 Protein, Avitag™,His Tag (MALS verified)
EPM-H82E8-structure
EPM-H82E8-sds
EPM-C5227 Rhesus macaque Rhesus macaque EpCAM / TROP1 Protein, His Tag
EPM-C5227-structure
EPM-C5227-sds
EPM-M5227 Mouse Mouse EpCAM / TROP1 Protein, His Tag (MALS verified)
EPM-M5227-structure
EPM-M5227-sds
EPM-H5223 Human Human EpCAM / TROP1 Protein, His Tag
EPM-H5223-structure
EPM-H5223-sds
EPM-H5254 Human Human EpCAM / TROP1 Protein, Fc Tag
EPM-H5254-structure
EPM-H5254-sds
YMF02023002 EpCAM CAR-T -01
ACRO Quality

Part of Bioactivity data

EPM-R82E3-MALS-HPLC
EpCAM MALS images

The purity of Biotinylated Rhesus macaque EpCAM / TROP1 Protein, His,Avitag (Cat. No. EPM-R82E3) is more than 90% and the molecular weight of this protein is around 28-40 kDa verified by SEC-MALS.

EPM-H82F9-MALS-HPLC
Biotinylated Human EpCAM, Fc,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human EpCAM, Fc,Avitag (Cat. No. EPM-H82F9) is more than 90% and the molecular weight of this protein is around 115-130 kDa verified by SEC-MALS.

Report

Synonym Name

EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1,4,KSA,M4S1,MIC18,MK1

Background

EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-EPCAM CAR-T cell therapy (Sinobioway) Phase 2 Clinical Beijing Sinobioway Bioengineering Group Co Ltd Liver Neoplasms; Stomach Neoplasms Details
A-337 A-337 Phase 1 Clinical Evive Biotech Ltd Neoplasms Details
Tefibazumab INH-H2002 Bristol-Myers Squibb Company Details
IMC-001 (Immunofoco) Phase 1 Clinical Suzhou Immunofoco Biotechnology Co Ltd Stomach Neoplasms; Pancreatic Neoplasms; Colorectal Neoplasms; Carcinoma, Hepatocellular Details
M-701 M-701 Phase 2 Clinical Wuhan Yzy Biopharma Co Ltd, Cspc-Nbp Pharmaceutical Co Ltd Hydrothorax; Neoplasms; Ascites; Pleural Effusion, Malignant; Carcinoma, Non-Small-Cell Lung Details
Catumaxomab LP000 Phase 3 Clinical Trion Research, Neovii Biotech Gmbh Ovarian Neoplasms; Stomach Neoplasms; Carcinoma; Neoplasms; Carcinoma, Ovarian Epithelial; Colonic Neoplasms; Ascites; Urinary Bladder Neoplasms; Breast Neoplasms Details
Oportuzumab monatox 4D5MOCB-ETA; VB4-845; VB-4847; B-4845; VB-845 Phase 3 Clinical Viventia Biotech Inc, Sesen Bio Inc Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Neoplasms, Squamous Cell; Urinary Bladder Neoplasms; Carcinoma, Squamous Cell; Mouth Neoplasms Details

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