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Your Position: Home > FABP6

FABP6

Brief Information

Name:Bile acid binding protein
Target Synonym:ILBP3,Gastrotropin,Intestinal Bile Acid-Binding Protein,Fatty Acid Binding Protein 6, Ileal,Intestinal 15 KDa Protein,I-BABP,Fatty Acid-Binding Protein 6,I-BALB,I-BAP,ILLBP,Ileal Bile Acid Binding Protein,ILBP,Fatty Acid Binding Protein 6,Illeal Lipid-Binding Protein,Ileal Lipid-Binding Protein,I-15P,FABP6,GT
Number of Launched Drugs:3
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Synonym Name

FABP6,ILBP,ILLBP,Gastrotropin,GT,I-15P,I-BABP,I-BALB,I-BAP

Background

Fatty acid-binding protein 6 (FABP6), is also known as Intestinal bile acid-binding protein (I-BABP), Ileal lipid-binding protein (ILBP), Intestinal 15 kDa protein (I-15P), Gastrotropin (GT). FABP6 is a cytoplasm protein which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. Isoform 2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Ileal protein FABP6 stimulates gastric acid and pepsinogen secretion. FABP6 seems to be able to bind to bile salts and bilirubins. Isoform 2 of FABP6 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Colestipol Hydrochloride Approved Pfizer Pharmaceuticals Ltd (China) Colestid United States Hyperlipidemias Pharmacia & Upjohn 1977-04-04 Protoporphyria, Erythropoietic; Hyperlipidemias Details
Colestilan MCl-196 Approved Mitsubishi Tanabe Pharma BindRen, Cholebine Japan Hypercholesterolemia Mitsubishi Tanabe Pharma 1999-07-01 Diabetes Mellitus, Type 2; Hyperphosphatemia; Hypercholesterolemia; Dyslipidemias; Renal Insufficiency, Chronic Details
Colesevelam Hydrochloride GT31-104HB; GT-31104; GT31-104 Approved Genzyme Corp CholestaGel, Welchol, Colestagel EU Hypercholesterolemia Genzyme Europe Bv 2000-05-26 Prediabetic State; Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Irritable Bowel Syndrome; Hypercholesterolemia; Diarrhea; Heterozygous familial hypercholesterolemia; Hyperlipoproteinemia Type II; Hyperlipidemias; Malabsorption Syndromes Details

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