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Your Position: Home > GITR Ligand

GITR Ligand

Brief Information

Name:Tumor necrosis factor ligand superfamily member 18
Target Synonym:AITRL,GITRL,TL6,UNQ149,PRO175,Glucocorticoid-induced TNF-related ligand,hGITRL,Activation-inducible TNF-related ligand
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
GIL-H524a Human Human GITR Ligand / TNFSF18 Protein, His Tag, active trimer (MALS verified)
GIL-H524a-sds
GIL-H5263 Human Human GITR Ligand / TNFSF18 Protein, Fc Tag, active trimer (MALS verified)
GIL-H5263-sds
GIL-H5249 Human Human GITR Ligand / TNFSF18 Protein, His Tag
GIL-H5249-structure
GIL-H5249-sds
GIL-H82F8 Human Biotinylated Human GITR Ligand / TNFSF18 Protein, Avitag™,Fc Tag
GIL-H82F8-structure
GIL-H82F8-sds
GIL-M526x Mouse Mouse GITR Ligand / TNFSF18 Protein, Fc Tag
GIL-M526x-structure
GIL-M526x-sds
GIL-H526a Human Human GITR Ligand / TNFSF18 Protein, Fc Tag
GIL-H526a-structure
GIL-H526a-sds
ACRO Quality

Part of Bioactivity data

GIL-H82F8-ELISA
GITR Ligand ELISA

Immobilized Human GITR, Fc Tag (Cat. No. GIR-H5254) at 2 μg/mL (100 μL/well) can bind Biotinylated Human GITR Ligand, Avitag,Fc Tag (Cat. No. GIL-H82F8) with a linear range of 4-63 ng/mL (QC tested).

Protocol
GIL-H5249-ELISA
GITR Ligand ELISA

Immobilized Human GITR Ligand, His Tag (Cat. No. GIL-H5249) at 2 μg/mL (100 μL/well) can bind Human GITR, Fc Tag (Cat. No. GIR-H5254) with a linear range of 0.1-4 ng/mL (QC tested).

Protocol

Synonym Name

TNFSF18,AITRL,TL6,hGITRL,GITR Ligand

Background

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.

Clinical and Translational Updates

Related Molecule

GITR

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