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Your Position: Home > HSP90AA1

HSP90AA1

Brief Information

Name:Heat shock protein HSP 90-alpha
Target Synonym:Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1,Heat Shock 90kDa Protein 1, Alpha,Heat Shock 90kD Protein 1, Alpha,HSP 86,HSP90A,HSPC1,Heat Shock Protein 90kDa Alpha Family Class A Member 1,Epididymis Secretory Sperm Binding Protein Li 65p,Epididymis Luminal Secretory Protein 52,Heat Shock 90kD Protein 1, Alpha-Like 4,Heat Shock 90kD Protein, Alpha-Like 4,HEL-S-65p,FLJ31884,HSPCAL1,HSPCAL4,HSP89A,HSP90N,Hsp103,Hsp89,Hsp90,EL52,HSPN,LAP2,Heat shock protein HSP 90-alpha,HSP86,LPS-asso
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
HS1-H513x Human Human HSP90AA1 / HSP86 Protein, GST Tag
HS1-H513x-structure
HS1-H513x-sds
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Synonym Name

HSP90AA1,HSP90A,HSP 86,HSP86,HSPC1,HSPCA,EL52,HSP89A,HSP90N,HSPCAL1,HSPCAL4,HSPN,Hsp89,Hsp90,LAP2

Background

Heat shock protein HSP 90-alpha (HSP90AA1 or HSP90A) is also known as Heat shock 86 kDa (HSP 86 or HSP86), Renal carcinoma antigen NY-REN-38, HSPC1, HSPCA, EL52, HSP89A, HSP90N, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2, which belongs to the heat shock protein 90 family. HSP90AA1 undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. HSP90AA1 interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Pimitespib TAS-116 Phase 1 Clinical Taiho Pharmaceutical Co Ltd, Otsuka Pharmaceutical Co Ltd Solid tumours; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung Details

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