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Your Position: Home > IGFBP-3

IGFBP-3

Brief Information

Name:Insulin-like growth factor binding protein III
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IG3-H5253 Human Human IGFBP-3 (28-291) Protein, Fc Tag
IG3-H5253-structure
IG3-H5253-sds
IG3-H52H9 Human Human IGFBP-3 Protein, His Tag
IG3-H52H9-structure
IG3-H52H9-sds
ACRO Quality

Part of Bioactivity data

IG3-H52H9-ELISA
IGFBP-3 ELISA

Immobilized Biotinylated Human IGF-II, Avitag,Fc Tag (Cat. No. IG2-H82F9) at 2 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (1 μg/well) plate can bind Human IGFBP-3, His Tag (Cat. No. IG3-H52H9) with a linear range of 0.01-0.313 μg/mL (QC tested).

Protocol

Synonym Name

IGFBP3,BP-53,IBP3

Background

Insulin-like growth factor-binding protein 3 is also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene. IGFBP3 forms a ternary complex of about 140 ~150 kDa with IGF1 or IGF2 and a glycoprotein insulin-like growth factor acid-labile subunit (ALS), thus alter the interaction of IGFs with their cell surface receptors. IGFBP3 exerts either proapoptotic or growth stimulatory effects depending upon the cellular context. Studies have shown that IGFBP3 can leads to the induction of apoptosis dependent or independent of the IGF-IGF receptor axis, accordingly acts as a negative regulator of tumorigenesis and progressing in certain carcinomas. The highest expression level is found in the nonparanchymal cells of the liver. Expression levels are also higher during extrauterine life and peak during puberty.

Clinical and Translational Updates

Related Molecule

IGF-I IGF-II

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