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Your Position: Home > IL-17F

IL-17F

Brief Information

Name:Interleukin-17F
Target Synonym:Cytokine ML-1,Interleukin-17F,IL17F,Interleukin 17F,IL-17F,CANDF6,ML-1,ML1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
ILF-H82Q9 Human Biotinylated Human IL-17F Protein, His,Avitag™ (MALS verified)
ILF-H82Q9-structure
ILF-H82Q9-sds
ILF-H5244 Human Human IL-17F Protein, His Tag (MALS verified)
ILF-H5244-structure
ILF-H5244-sds
ILF-C5243 Cynomolgus Cynomolgus IL-17F Protein, His Tag
ILF-C5243-structure
ILF-C5243-sds
ILF-M5249 Mouse Mouse IL-17F Protein, His Tag
ILF-M5249-structure
ILF-M5249-sds
ILF-H4240 Human Human IL-17F (H161R) Protein, His Tag
ILF-H4240-structure
ILF-H4240-sds
ACRO Quality

Part of Bioactivity data

ILF-M5249-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Mouse IL-17F, His Tag (Cat. No. ILF-M5249) with an affinity constant of 2.99 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ILF-H5244-BLI
IL-17F BLI

Loaded Human IL-17 RA, Fc Tag (Cat. No. ILA-H5257) on Protein A Biosensor, can bind Human IL-17F, His Tag (Cat. No. ILF-H5244) with an affinity constant of 219 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

Synonym Name

IL-17F,Interleukin-17F,Cytokine ML-1

Background

Interleukin-17F (IL17F) is also known as Interleukin-24 (IL24), Cytokine ML-1, is a secreted disulfide-linked homodimer which belongs to the IL-17 family. There are at least six members of the IL-17 family in humans and in mice: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25) and IL-17F (also called IL-24). IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F / IL-24 is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL17F / Interleukin-24 stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL17F / IL-24 stimulates PBMC and T-cell proliferation and Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6).

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Recombinant human IL-17A/F humanized antibody (Livzon Pharmaceutical Group) LZM－012; LZM012 Phase 2 Clinical Livzon Pharmaceutical Group Inc, Beijing Kanova Biomedical Technology Co Ltd Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis Details
HY-1770 HY-1770; HY1770; HT-17; HT17 Phase 1 Clinical Suzhou Pharmavan Co Ltd Dermatitis, Atopic; Plaque psoriasis Details
Sonelokimab M-1095; ALX-0761; MSB-0010841 Phase 2 Clinical Ablynx Nv Psoriasis; Hidradenitis Suppurativa Details
DMT-310 DMT-310 Phase 2 Clinical Dermata Rosacea Details

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