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Your Position: Home > IL-22

IL-22

Brief Information

Name:Interleukin-22
Target Synonym:MGC79384,IL-TIF,ZCYTO18,UNQ3099/PRO10096,ILTIF,Cytokine Zcyto18,IL-22,IL22,Interleukin 22,IL-10-Related T-Cell-Derived Inducible Factor,IL-10-Related T-Cell-Derived-Inducible Factor,Interleukin-22,TIFIL-23,IL-D110,IL-21,TIFa,MGC79382
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL2-H8247 Human Biotinylated Human IL-22 Protein, His,Avitag™
IL2-H8247-structure
IL2-H8247-sds
IL2-H524a Human Human IL-22 Protein, His Tag
IL2-H524a-structure
IL2-H524a-sds
ACRO Quality

Part of Bioactivity data

IL2-H524a-ELISA
IL-22 ELISA

Immobilized Human IL-22, His Tag (Cat. No. IL2-H524a) at 5 μg/mL (100 μL/well) can bind Anti-Human IL-22 MAb with a linear range of 0.5-16 ng/mL (QC tested).

Protocol
IL2-H8247-ELISA
IL-22 ELISA

Immobilized Biotinylated Human IL-22, His,Avitag (Cat. No. IL2-H8247) at 1 μg/mL (100 μL/well)on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate. can bind Human IL-22 Antibody with a linear range of 0.1-4 ng/mL (QC tested).

Protocol

Synonym Name

IL-22,IL-TIF,ZCYTO18

Background

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ARGX-112 LEO-138559; LP-0145; ARGX-112 Phase 2 Clinical Leo Pharma Inc, Argenx Se Dermatitis, Atopic Details

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