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Your Position: Home > TrkC

TrkC

Brief Information

Name:Neurotrophic tyrosine kinase receptor type 3
Target Synonym:Trk-C,NTRK3,NT-3 growth factor receptor,TrkC tyrosine kinase,Neurotrophic Receptor Tyrosine Kinase 3,Neurotrophic Tyrosine Kinase, Receptor, Type 3,GP145-TrkC,TRKC,ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein,Tyrosine Kinase Receptor C,ETV6-NTRK3 Fusion,Gp145(TrkC),Receptor, trkC,EC 2.7.10,EC:2.7.10.1,Neurotrophic Tyrosine Kinase Receptor Type 3,EC 2.7.10.1
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP189 Human HEK293/Human TrkC Stable Cell Line
TRC-H5256 Human Human TrkC / NTRK3 Protein, Fc Tag (MALS verified)
TRC-H5256-structure
TRC-H5256-sds
ACRO Quality

Part of Bioactivity data

TRC-H5256-MALS-HPLC
TrkC MALS images

The purity of Human TrkC Protein, Fc Tag (Cat. No. TRC-H5256) is more than 90% and the molecular weight of this protein is around 185-215 kDa verified by SEC-MALS.

TRC-H5256-ELISA
TrkC ELISA

Immobilized Human NT-3 / Neurotrophin-3 Protein at 2 μg/mL (100 μL/well) can bind Human TrkC Protein, Fc Tag (Cat. No. TRC-H5256) with a linear range of 0.3-5 ng/mL (QC tested).

Protocol

Synonym Name

NTRK3,TRKC,gp145

Background

TrkC tyrosine kinase is also known as Trk-C receptor, NT-3 growth factor receptor and neurotrophic tyrosine kinase receptor type 3, is a member of the NTRK family which mediates the biological activities of neurotrophins. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. TrkC is part of the large family of receptor tyrosine kinases which includes TrkA and TrkB. Also, there are other neurotrophic factors structurally related to NT-3: NGF, BDNF and NT-4. While TrkB mediates the effects of BDNF, NT-4 and NT-3, TrkA is bound and thereby activated only by NGF. Further, TrkC binds and is activated only by NT-3. TrkB binds BDNF and NT-4 more strongly than it binds NT-3. TrkC binds NT-3 more strongly than TrkB does. Upon neurotrophin binding, TrkC phosphorylates itself and down stream molecules of the related pathways, and therefore mediates the NT3-stimulated neurotrophic effects. This protein thus leads to cell proliferation, differentiation and plays a role in the development of proprioceptive neurons.

Clinical and Translational Updates

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