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Your Position: Home > Gremlin

Gremlin

Brief Information

Name:Gremlin-1
Target Synonym:Cell proliferation-inducing gene 2 protein,Cysteine knot superfamily 1, BMP antagonist 1,DAN domain family member 2,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2,CKTSF1B1,DAND2,DRM
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
GR1-H5254 Human Human Gremlin / GREM1 Protein, Fc Tag
GR1-H5254-structure
GR1-H5254-sds
GR1-H52H3 Human Human Gremlin / GREM1 Protein, His Tag
GR1-H52H3-structure
GR1-H52H3-sds
ACRO Quality

Part of Bioactivity data

GR1-H52H3-ELISA
Gremlin ELISA

Immobilized Human BMP-2, Tag Free (Cat. No. BM2-H4117) at 2 μg/mL (100 μL/well) can bind Human Gremlin, His Tag (Cat. No. GR1-H52H3) with a linear range of 0.02-0.313 μg/mL (QC tested).

Protocol
GR1-H5254-ELISA
Gremlin ELISA

Immobilized Human BMP-2 Protein, premium grade (Cat. No. BM2-H4117) at 2 μg/mL (100 μL/well) can bind Human Gremlin, Fc Tag (Cat. No. GR1-H5254) with a linear range of 0.2-8 ng/mL (QC tested).

Protocol

Synonym Name

GREM1,CKTSF1B1,DAND2,DRM,PIG2

Background

Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Clinical and Translational Updates

Related Molecule

BMP-2

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ginisortamab UCB-6114 Phase 2 Clinical Ucb Biopharma Srl Solid tumours; Neoplasms Details
TST-003 TST-003 Phase 1 Clinical Mabspace Biomedicine (Suzhou) Co Ltd Solid tumours Details

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