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Your Position: Home > LRRC32

LRRC32

Brief Information

Name:Transforming growth factor beta activator LRRC32
Target Synonym:Leucine Rich Repeat Containing 32,D11S833E,Garpin,Leucine-Rich Repeat-Containing Protein 32,LRRC32,Transforming Growth Factor Beta Activator LRRC32,GARP,Glycoprotein A Repetitions Predominant
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LR2-H5256 Human Human LRRC32 / GARP / Garpin Protein, Fc Tag
LR2-H5256-structure
LR2-H5256-sds
ACRO Quality

Part of Bioactivity data

LR2-H5256-BLI
LRRC32 BLI

Loaded Human LRRC32, Fc Tag (Cat. No. LR2-H5256) on AHC Biosensor, can bind Human TGFB1, His Tag (Cat. No. TG1-H524x) with an affinity constant of 0.239 μM as determined in BLI assay (ForteBio Octet Red96e) (QC tested).

Protocol
LR2-H5256-ELISA
LRRC32 ELISA

Immobilized Human LRRC32, Fc Tag (Cat. No. LR2-H5256) at 2 μg/mL (100 μL/well) can bind Cynomolgus Latent TGF-Beta 1 (C33S), His Tag (Cat. No. TG1-C5243) with a linear range of 0.039-1.25 μg/mL (Routinely tested).

Protocol

Synonym Name

GARP,Garpin,D11S833E

Background

Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

Clinical and Translational Updates

Related Molecule

Latent TGFB1

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Livmoniplimab ABBV151; MGH-8; ARGX-115; AGRX-115 Argenx Se, Abbvie Inc Details
DS-1055 DS-1055a; DS-1055 Phase 1 Clinical Daiichi Sankyo Co Ltd Solid tumours; Neoplasms; Neoplasm Metastasis Details
HLX-60 HLX-60 Phase 1 Clinical Shanghai Henlius Biologics Co Ltd Solid tumours; Lymphoma Details

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