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Your Position: Home > Galectin-9

Galectin-9

Brief Information

Name:Galactoside-binding lectin Galectin 9
Target Synonym:Ecalectin,Tumor antigen HOM-HD-21,Galectin-9,Lectin, Galactoside-Binding, Soluble, 9,LGALS9
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LG9-H82H3 Human Biotinylated Human Galectin-9 / LGALS9 Protein, His,Avitag™
LG9-H82H3-structure
LG9-H82H3-sds
LG9-H5244 Human Human Galectin-9 / LGALS9 Protein, His Tag
LG9-H5244-structure
LG9-H5244-sds
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Part of Bioactivity data

LG9-H82H3-SPR
Galectin-9 SPR

Human TIM-3 (22-200) Protein, Fc Tag (Cat. No. TM3-H5258) immobilized on CM5 Chip can bind Biotinylated Human Galectin-9, His,Avitag (Cat. No. LG9-H82H3) with an affinity constant of 7.66 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
LG9-H5244-SPR
Galectin-9 SPR

Human TIM-3 (22-200) Protein, Fc Tag (Cat. No. TM3-H5258) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human Galectin-9, His Tag (Cat. No. LG9-H5244) with an affinity constant of 57 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

Galectin-9,LGALS9,Ecalectin

Background

Galectin-9 (LGALS9) is also known as tumor antigen HOM-HD-21 and ecalectin. Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. As for Galectin-9, it has high affinity for the Forssman pentasaccharide, and it is also the ligand for HAVCR2/TIM3. Forthermore, Galectin-9 stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

Clinical and Translational Updates

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