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Your Position: Home > EphA2

EphA2

Brief Information

Name:Ephrin type-A receptor 2
Target Synonym:EC:2.7.10.1,Epithelial Cell Receptor Protein Tyrosine Kinase,Ephrin type-A receptor 2,Epithelial cell kinase,EPHA2,EPH Receptor A2,Tyrosine-Protein Kinase Receptor ECK,ECK,Soluble EPHA2 Variant 1,EC 2.7.10.1,CTRCT6,ARCC2,CTPP1,CTPA,Receptor, EphA2,EC 2.7.10
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
EP2-R52H5 Rat Rat EphA2 Protein, His Tag (MALS verified)
EP2-R52H5-structure
EP2-R52H5-sds
EP2-H82E4 Human Biotinylated Human EphA2 Protein, His,Avitag™ (MALS verified)
EP2-H82E4-structure
EP2-H82E4-sds
EP2-H52H4 Human Human EphA2 Protein, His Tag (MALS verified)
EP2-H52H4-structure
EP2-H52H4-sds
ACRO Quality

Part of Bioactivity data

EP2-H82E4-MALS-HPLC
EphA2 MALS images

The purity of Biotinylated Human EphA2 Protein, His,Avitag (Cat. No. EP2-H82E4) is more than 95% and the molecular weight of this protein is around 55-70 kDa verified by SEC-MALS.

EP2-H82E4-ELISA
EphA2 ELISA

Immobilized Biotinylated Human EphA2 Protein, His,Avitag (Cat. No. EP2-H82E4) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human Ephrin-A1, Fc Tag (Cat. No. EF1-H5251) with a linear range of 0.1-1 ng/mL (QC tested).

Protocol

Synonym Name

EphA2

Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Clinical and Translational Updates

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