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• Screen for neutralizing antibodies blocking the stimulation of human NGF protein.
• Screen for human TrkA small molecule inhibitor
Expression analysis of human TrkA on Human TrkA (Luc) HEK293 Reporter Cell by FACS.
Cell surface staining was performed on Human TrkA (Luc) HEK293 Reporter Cell or negative control cell using PE-labeled anti-human TrkA antibody.
Inhibition of human NGF protein-induced reporter activity by anti-human NGF neutralizing antibody.
This reporter cell was incubated with serial dilutions of antibodies in the presence of human NGF protein (Cat. No. BEF-H5214) with a final concentration of 0.05 μg/mL. The EC50 of anti-human NGF neutralizing antibody is approximately 0.0212 μg/mL
Inhibition of human NGF protein-induced reporter activity by human TrkA small molecule inhibitor.
This reporter cell was incubated with serial dilutions of inhibitors in the presence of human NGF protein (Cat. No. BEF-H5214) with a final concentration of 0.03 μg/mL. The EC50 of human TrkA small molecule inhibitor was approximately 6.725 nM.
Response to human NGF protein (RLU).
The Human TrkA (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of human NGF protein (Cat. No. BEF-H5214). The EC50 was approximately 0.02679 μg/mL.
Response to human NGF protein (FOLD).
The Human TrkA (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of human NGF protein (Cat. No. BEF-H5214). The max induction fold was approximately 12.43.
Passage stability analysis by human NGF protein stimulation.
The continuously growing Human TrkA (Luc) HEK293 Reporter Cell was stimulated with serial dilutions of human NGF protein (Cat. No. BEF-H5214) stimulated response demonstrates passage stabilization (fold induction and EC50) across passage 13-22.
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BY USE OF THIS PRODUCT, RESEARCHER AGREES TO BE BOUND BY THE FOLLOWING TERMS OF LIMITED USE OF THIS CELL LINE PRODUCT.
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
CD3 proteins and a collection of for bispecific antibody development which are of high specificity and bioactivities and suitable for immunization, antibody screening.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
The MABSOL biotinylated protein collection includes more than a hundred commonly studied drug targets and biomarker proteins.
Comprehensive cytokines including IL families, growth factors, chemokines, TNFs, etc. These products are HEK293 expressed and nearly in authentic structure, high purity and bioactivity, cell based assay/SPR/BLI verified.
To support preclinical/clinical immunogenicity and PK analysis, ACROBiosystems has developed a series of high-affinity anti-idiotypic antibodies. Our pipeline covers five hot targets including adalimum*b, rituxim*b, cetuxim*b, trastuzum*b, and bevacizum*b.
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