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Your Position: Home > Antibody > CD45 (LCA) > HGS-S261

Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3)

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  • Background
    Recombinant Monoclonal Anti-CD45(LCA) Antibody, Rabbit (1C3) is a CD45(LCA) primary antibody for IHC application. Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • Key parameter
    Host SpeciesRabbit
    IsotypeIgG
    Clone1C3
    ApplicationIHC
    Property1:1000
    StateLiquid
    Positive ControlHuman Tonsil Tissues
    ClonalityMonoclonal
    Research FieldCancer Drug Targets
    SourceRabbit
    SynonymPTPRC, CD45, GP180, LCA, T200
  • Experiment Protocol
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. The shelf life is 30 days from the date of opening.
Typical Data
Control Sample
 CD45 (LCA) CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S261 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE CD45 (LCA) CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S261 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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