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Your Position: Home > Protein > IL-23A > ILA-H525h

Human IL-23A Protein, Fc Tag

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  • Synonym
    IL23A,IL-23,IL-23A,IL23P19,P19,SGRF
  • Source
    Human IL-23A Protein, Fc Tag(ILA-H525h) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (Accession # Q9NPF7).
    Predicted N-terminus: Arg 20
  • Molecular Characterization
    IL-23A Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 45.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method / rFC method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
IL-23A SDS-PAGE

Human IL-23A Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 IL-23A ELISA

Immobilized Human IL-23A Protein, Fc Tag (Cat. No. ILA-H525h) at 1 μg/mL (100 μL/well) can bind Mirikizumab with a linear range of 0.002-0.25 μg/mL (QC tested).

  • Background
    Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:2 Details
  • Number of Drugs in Clinical Trials:15 Details
  • Latest Research Phase:Approved

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