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Your Position: Home > Protein > Erythropoietin R > ERR-C52H3

Cynomolgus Erythropoietin R Protein, His Tag (MALS & SPR verified)

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INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    EPOR
  • Source
    Cynomolgus Erythropoietin R Protein, His Tag(ERR-C52H3) is expressed from human 293 cells (HEK293). It contains AA Pro 26 - Pro 250 (Accession # EHH59220.1).
    Predicted N-terminus: Pro 26
    Request for sequence
  • Molecular Characterization
    Erythropoietin R Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 26.7 kDa. The protein migrates as 28-29 kDa and 30-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >90% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Erythropoietin R SDS-PAGE

Cynomolgus Erythropoietin R Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Erythropoietin R MALS images

The purity of Cynomolgus Erythropoietin R Protein, His Tag (Cat. No. ERR-C52H3) is more than 95% and the molecular weight of this protein is around 20-35 kDa verified by SEC-MALS.

Report
Bioactivity-SPR
Erythropoietin R SPR

Cynomolgus Erythropoietin R Protein, His Tag (Cat. No. ERR-C52H3) immobilized on CM5 Chip can bind Human EPO Protein, premium grade (Cat. No. EPO-H4214) with an affinity constant of 0.613 nM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
  • Background
    This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
  • Clinical and Translational Updates

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