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| Cat. No. | Components | Size |
| GMP-CM4101 | CelThera™ GMP MSC Expansion Medium (Phenol Red-free) | 1000 mL |
| GMP-CM41S1 | CelThera™ GMP MSC Expansion Medium Supplement | 3 mL |
Note: A complimentary bottle of CelThera™ GMP Phenol Red Solution (0.5%) (Cat# GMP-PI1100) is supplied with this kit. For cell culture procedures requiring phenol red indicator, add 1.5 mL of this solution to 1 L of CelThera™ GMP MSC Expansion Medium (Phenol Red-free) and mix thoroughly.
Compared to traditional or xeno-free medium, this AOF formulation reduces potential pathogenic microorganism risks, improves batch consistency, and avoids undefined serum component interference with MSC behavior.
CelThera™ GMP MSC Expansion Medium (Phenol Red-free) is stable for 12 months when stored under 2-8°C, protect from light.
CelThera™ GMP MSC Expansion Medium Supplement is stable for 12 months when stored under -20°C or below, protect from light.
Different sources of MSCs P4 (hUC-MSCs, hBM-MSCs, hAT-MSCs) were cultured and passaged to P7. The cell expansion results demonstrated that CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41) (add 5% PLT) exhibited excellent performance in supporting cell growth and proliferation.
Different sources of MSCs P4 (hUC-MSCs, hBM-MSCs, hAT-MSCs) were cultured and passaged to P7. Cell viability results showed that CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41) (add 5% PLT) maintained excellent cell viability.
hUC-MSCs Expanded in AcroBio Medium Display Multi-Lineage Differentiation Potential.
hUC-MSC expanded in CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41) differentiated into (A) osteoblasts (Alizarin Red S staining; P7), (B) adipocytes (Oil Red O staining; P7), (C) chondrocytes (Alcian Blue staining; P7).
hUC-derived MSCs were cultured and expanded in CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41). At P7 MSCs were stained for mesenchymal markers .MSCs expressed CD73, CD90, CD105 ＞95%，HLA-DR, CD45, CD34＜5%.
hBM-derived MSCs were cultured and expanded in CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41). At P7 MSCs were stained for mesenchymal markers .MSCs expressed CD73, CD90, CD105 ＞95%，HLA-DR, CD45, CD34＜5%.
hAT-derived MSCs were cultured and expanded in CelThera™ GMP MSC Expansion Medium (Phenol Red-free) (Cat. No. GMP-MSCCM41). At P7 MSCs were stained for mesenchymal markers .MSCs expressed CD73, CD90, CD105 ＞95%，HLA-DR, CD45, CD34＜5%.
ACROBiosystems GMP grade mediums are produced under a quality management system and in compliance with relevant guidelines: Ph. Eur General Chapter 5.2.12 Raw materials of biological origin for the production of cell-based and gene therapy medicinal products; USP <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products; ISO 20399: 2022(E), Biotechnology — Ancillary materials present during the production of cellular therapeutic products and gene therapy products
ACROBiosystems Quality Management System Contents：
Designed and Manufactured under ISO 9001:2015 and ISO 13485:2016.
Animal-Free materials
Materials purchased from the approved suppliers by QA
ISO 5 clean room for filling
Qualified personnel
Quality-related documents review and approve by QA
Fully batch production and control records
Equipment maintenance and calibration
Validation of analytical procedures
Stability studies conducted
Comprehensive regulatory support files
Request For Regulatory Support Files（RSF）
ACROBiosystems provide rigorous quality control tests (fully validated equipment, processes and test methods) on our GMP grade products to ensure that they meet stringent standards in terms of purity, safety, activity and inter-batch stability, and each bulk QC lot mainly contains the following specific information:
pH
Sterility
Osmolality
Endotoxin Level
Functionality
Mycoplasma testing
Batch-to-batch consistency
ACROBiosystems GMP grade products are designed for research, manufacturing use or ex vivo use. CAUTION: Not intended for direct human use.
All products are warranted to meet ACROBiosystems Inc.’s (“ACRO”) published specifications when used under normal laboratory conditions.
ACRO DOES NOT MAKE ANY OTHER WARRANTY OR REPRESENTATION WHATSOEVER, WHETHER EXPRESS OR IMPLIED, WITH RESPECT TO ITS PRODUCTS. IN PARTICULAR, ACRO DOES NOT MAKE ANY WARRANTY OF SUITABILITY, NONINFRINGEMENT, MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.
NOT WITH STANDING ANY OTHER PROVISIONS OF THESE TERMS AND/OR ANY OTHER AGREEMENT BETWEEN ACRO AND PURCHASER FOR THE PURCHASE OF THE PRODUCTS, ACRO’S TOTAL LIABILITY TO PURCHASER ARISING FROM OR IN RELATION TO THESE TERMS, AN AGREEMENT BETWEEN THE PARTIES OR THE PRODUCTS, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE SHALL BE LIMITED TO THE TOTAL AMOUNT PAID BY PURCHASER TO ACRO FOR THE RELEVANT PRODUCTS. IN NO EVENT WILL ACRO BE LIABLE FOR THE COST OF PROCUREMENT OF SUBSTITUTE GOODS.
The following terms are offered to you upon your acceptance of these End User Terms of Use of Product. By using this product, you indicate your acknowledgment and agreement to these End User Terms of Use of Product. If you do not agree to be bound by and comply with all of the provisions of these End User Terms of Use of Product, you should contact your supplier of the product and make arrangements to return the product.
The End User is aware that ACROBiosystems Inc. and its affiliate (“ACRO”) sell GMP grade products designed for research, manufacturing use or ex vivo use and not intended for human in vivo applications. The End User further agrees, as a condition of the sales of ACRO’s GMP grade products that: a) the End User will not use this GMP grade product in any procedure wherein the product may be directly or indirectly administered to humans, unless the End User has obtained, or prior to their use will have obtained, an Investigational New Drug (IND) exemption from the FDA and will use the product only in accordance with the protocols of such IND and of the Institutional Review Board overseeing the proposed research, or b) the End User will use the products outside of the United States in accordance with the protocols of research approved by the applicable review board or authorized ethics committee and regulatory agencies to which the End User is subject to in their territory.
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
ACROBiosystems developed a series of GMP grade cytokines under the GMP grade quality management system. Those products are all suitable for T/NK cell generation, activation, and proliferation in cell therapy research.
50+ targets designed for CAR detection, including PE/FITC/biotin labeled proteins. The key reagents for CD19 and BCMA were FDA DMF filed which can support your IND, NDA and BLA process.
GMP grade cytokines, reagents for cell activation, gene edition, DNA/RNA removal, etc. Particularly focus on product design, quality control and solution-based support to link each phase of your cell and gene therapy journey.
Full length multi-pass TPs with stabilized structure and high bioactivity for immunization, antibody screening, cell based assay and CAR detection, including hot CD20, Claudin 18.2， CD133, GPRC5D，CCR8, CCR5, etc.
CD3 proteins and a collection of for bispecific antibody development which are of high specificity and bioactivities and suitable for immunization, antibody screening.
A series of immune checkpoints including classic co-inhibitory and co-stimulatory receptors. The comprehensive catalog contains 100+ targets with various species and tags, and the high-quality proteins are in good batch-to-batch consistency.
To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
Comprehensive collection of Fc receptor proteins, including their common variants, which can help expedite your antibody development.
The MABSOL biotinylated protein collection includes more than a hundred commonly studied drug targets and biomarker proteins.
Comprehensive cytokines including IL families, growth factors, chemokines, TNFs, etc. These products are HEK293 expressed and nearly in authentic structure, high purity and bioactivity, cell based assay/SPR/BLI verified.
To support preclinical/clinical immunogenicity and PK analysis, ACROBiosystems has developed a series of high-affinity anti-idiotypic antibodies. Our pipeline covers five hot targets including adalimum*b, rituxim*b, cetuxim*b, trastuzum*b, and bevacizum*b.
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