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Your Position: Home > Protein > Transferrin R > TFR-C5263

Cynomolgus Transferrin R / CD71 Protein, Fc Tag (MALS verified)

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  • Synonym
    CD71, TFRC, TFR, sTfR, TfR1, Trfr, T9, p90
  • Source
    Cynomolgus Transferrin R Protein, Fc Tag(TFR-C5263) is expressed from human 293 cells (HEK293). It contains AA Cys 89 - Phe 760 (Accession # G8F602-1).
    Predicted N-terminus: Pro
  • Molecular Characterization
    Transferrin R Structure

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 101.6 kDa. The protein migrates as 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method / rFC method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Transferrin R SDS-PAGE

Cynomolgus Transferrin R Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Transferrin R MALS images

The purity of Cynomolgus Transferrin R Protein, Fc Tag (Cat. No. TFR-C5263) is more than 90% and the molecular weight of this protein is around 195-240 kDa verified by SEC-MALS.

Bioactivity-ELISA
 Transferrin R ELISA

Immobilized Human Transferrin Protein, His Tag (Cat. No. TRN-H52H3) at 5 μg/mL (100 μL/well) can bind Cynomolgus Transferrin R Protein, Fc Tag (Cat. No. TFR-C5263) with a linear range of 0.2-16 ng/mL (QC tested).

  • Background
    CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukomia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.
  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:9 Details
  • Latest Research Phase:Approved

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