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Your Position: Home > Protein > CD117 > CD7-M52H4

White-tufted-ear marmoset CD117 / c-kit Protein, His Tag (MALS verified)

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INTRODUCTION
QC & Assay Protocol
Citation & Background
  • Synonym
    CD117,SCFR,c-Kit,KIT
  • Source
    White-tufted-ear marmoset CD117 Protein, His Tag(CD7-M52H4) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Pro 520 (Accession # Q76II0 ).
    Predicted N-terminus: Gln 26
    Request for sequence
  • Molecular Characterization
    CD117 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 57.8 kDa. The protein migrates as 70-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
CD117 SDS-PAGE

White-tufted-ear marmoset CD117 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
CD117 MALS images

The purity of White-tufted-ear marmoset CD117 Protein, His Tag (Cat. No. CD7-M52H4) is more than 90% and the molecular weight of this protein is around 70-100 kDa verified by SEC-MALS.

Report
  • Background
    This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
  • Clinical and Translational Updates

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