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This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 76 kDa. The protein migrates as 100-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
Human IL-17 RC (21-465) Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
The purity of Human IL-17 RC (21-465) Protein, Fc Tag (Cat. No. ILC-H5258) is more than 90% and the molecular weight of this protein is around 95-130 kDa verified by SEC-MALS.
Immobilized Human IL17A, premium grade (Cat. No. ILA-H5219) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC (21-465) Protein, Fc Tag (Cat. No. ILC-H5258) with a linear range of 2-78 ng/mL (QC tested).
Immobilized Human IL-17F (H161R), His Tag (Cat. No. ILF-H4240) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC (21-465) Protein, Fc Tag (Cat. No. ILC-H5258) with a linear range of 0.02-0.625 μg/mL (Routinely tested).
Human IL-17 RC (21-465) Protein, Fc Tag (Cat. No. ILC-H5258) immobilized on CM5 Chip can bind Human IL17A, premium grade (Cat. No. ILA-H5219) with an affinity constant of 0.718 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Human IL-17 RC (21-465) Protein, Fc Tag (Cat. No. ILC-H5258) immobilized on CM5 Chip can bind Biotinylated Human IL17A, His,Avitag (Cat. No. ILA-H82Q1) with an affinity constant of 2.24 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Emerging VoCs, Omicron, Delta, Beta, Alpha mutants and so on, including RBD, S trimer, S1, NTD, NP, etc. These mutants are of high purity and bioactivity and can be used to evaluate the efficacy of the antibodies and vaccination.
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To meet the needs of ADCs development, ACROBiosystems can provide: A variety of high-quality target proteins; MMPs/Cathepsin/uPA for cleavable linker; Anti-payload antibodies & anti-idiotypic antibodies for immunogenicity and PK analysis; SPR/BLI analytical and ADA development service.
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To support preclinical/clinical immunogenicity and PK analysis, ACROBiosystems has developed a series of high-affinity anti-idiotypic antibodies. Our pipeline covers five hot targets including adalimum*b, rituxim*b, cetuxim*b, trastuzum*b, and bevacizum*b.
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