로그인 회원가입
icon_bulk_order대량 주문 Acrobiosystems for English
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Protein > FGF-7 > FG7-H5318

Human FGF-7 / KGF Protein, premium grade (CHO)

GMP version GMP-FG7H35 is now available for seamless transition.

Order Now

  • Synonym
    FGF-7,Fibroblast growth factor 7,HBGF-7,Keratinocyte growth factor,KGF
  • Source
    Human FGF-7 Protein, premium grade (CHO)(FG7-H5318) is expressed from CHO cells. It contains AA Cys 32 - Thr 194 (Accession # P21781-1).
    Predicted N-terminus: Cys 32
    It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.
    GMP-FG7H35 is the GMP version of this FG7-H5318. These two proteins display indistinguishable performance profiles, thereby ensuring a seamless transition for end users from early preclinical stag to later clinical phases.
  • Molecular Characterization
    FGF-7 Structure

    This protein carries no "tag".

    The protein has a calculated MW of 18.9 kDa. The protein migrates as 27 kDa±3 kDa under reducing (R) condition, and 26 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.01 EU per μg by the LAL method / rFC method.
  • Host Cell Protein
    <0.5 ng/µg of protein tested by ELISA.
  • Host Cell DNA
    <0.02 ng/μg of protein tested by qPCR.
  • Sterility
    Negative
  • Mycoplasma
    Negative
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 24 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
FGF-7 SDS-PAGE

Human FGF-7 Protein, premium grade (CHO) on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-CELL BASE
 FGF-7 CELL

Human FGF-7 Protein, premium grade (CHO) (Cat. No. FG7-H5318) stimulates Human FGF-7 (Luc) HEK293 Reporter cells. The specific activity of Human FGF-7 Protein, premium grade (CHO) is > 5.00 x 10^5 IU/mg, which is calibrated against human FGF-7 WHO International Standard (NIBSC code: 03/150) (QC tested).

Bioactivity-ELISA
 FGF-7 ELISA

Immobilized Human FGF-7 Protein, premium grade (CHO) (Cat. No. FG7-H5318) at 5 μg/mL (100 μL/well) can bind Human FGF R2 (IIIb), Fc Tag (Cat. No. FGB-H5256) with a linear range of 0.3-10 ng/mL (Routinely tested).

  • Background
    Fibroblast growth factor (FGF) 7 (is also known as Keratinocyte growth factor (KGF)), a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues. As a well-characterized paracrine growth factor for tissue growth and regeneration, fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease and cancer. The stromal-derived FGFs, such as FGF7 and FGF10, control epithelial cell resident FGFR2IIIb activities, promote net tissue homeostasis, and restraint tumor cells from progression to malignancy.
  • Clinical and Translational Updates

Comments (0)

Drug Candidate Licensing

more

Datasheet & Documentation

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop